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Personalized Drug Design for Comprehensive Cancer Care
At Envita Medical Centers, a world-class integrative center for precision oncology, we develop personalized drugs
tailored to each patient’s individual genetic needs. Cancer is a disease of genetic mutations, signaling, and
immune system evasion, and these factors vary from person to person even with the same type and stage of cancer,
pointing to the need for customization.
Our custom-built medicines target each patient’s specific cancer cell factors, based on the findings of our
detailed ultra analytes testing, which identifies genomic, immunotherapy, and key algorithm analytes linked to
growth factors and causes of cancer growth and spread. This personalized precision oncology approach goes far
beyond standard chemotherapy, radiation, or surgery alone.
Envita’s Custom Drug Design
Our custom-built medicines target each patient’s
specific cancer cell factors, based on the findings of our detailed ultra analytes testing for genomic,
transcriptomic, proteomic, and metabolomic data.
The Envita Algorithm
Genomics
Transcriptomics
Proteomics
and
Metabolomics
Using this information, our physicians custom-build medications with the
highest probability of enhancing tumor kill while strengthening the patient’s overall immune system.
Envita’s in-depth, real-time ultra analytes testing reveals each patient’s key unique cancer drivers. Armed with
this information, we custom-build medications with the highest probability of enhancing tumor kill while
strengthening the overall immune system of each individual patient. In our clinical experience, both these aspects
are crucial for holistic cancer treatment, because only a robust immune system can prevent cancer recurrence or
metastasis/spread, helping you progress towards the goal of long-term remission.
With such levels of personalization, we have carved out a niche for our patients to achieve next level
targeting and treatment.
With the aim of holistic recovery, our expert physicians, pharmacists, and chemists, customize medications at our
in-house pharmacy specific to our patients’ needs. Our goal is to help in improving patients’ quality of life,
increasing longevity, and reducing toxicity. Our chemists work alongside pharmacists and doctors to combine the
latest in conventional medicine innovation with advanced natural therapies to optimize treatment efficacy for our
patients.
The Need for Customization
Envita’s Ultra Analytes Liquid Biopsy analyses CTCs (Circulating Tumor Cells) in the patient’s blood
samples to unravel each patient’s individual biomarkers. There may not be commercially available drugs to
target all biomarkers, immune system, and metabolic and genomic drivers of each patient’s cancer which is
why our in-house pharmacy is crucial for developing treatments for these targets.
Biomarkers are attributes of cancer cells containing specific
chemotherapy and immunotherapy targets. By harvesting the latest biomarker information through our
extensive genomic analysis, our expert physicians can identify actionable targets for chemotherapeutic
agents, adjuvant therapies, and immunotherapies your body is most likely to respond to.
Biomarkers are attributes of cancer cells containing specific chemotherapy and
immunotherapy targets. By harvesting the latest biomarker information through our extensive genomic analysis, our
expert physicians can identify actionable targets for chemotherapeutic agents, adjuvant therapies, and
immunotherapies your body is most likely to respond to.
This critical information is passed on to our expert chemists who custom-design drugs for each of
our patients. Our sophisticated algorithms offer a strong foundation to the process of custom-building medications.
In a hospital or medical center setting, custom-building medication is not a viable option. In general, doctors
order medications, mix them into a solution, and deliver it as standard regimen, based on the NCCN (National
Comprehensive Cancer Network) guidelines. Envita goes way beyond this standard regimen, to custom build and design
medications based on patient markers, thus greatly increasing combinations which have better chances of working
effectively on their individual actionable targets. This personalized drug design method gives our patients a
better chance to heal holistically.
Types of Drugs
We use a combination of FDA approved drugs, repurposed drugs, and custom compounded adjuvants, to treat
the cancer at its core. Some of these drugs are administered intravenously or orally, while others are
deployed through proprietary interventional radiology procedures, which are minimally invasive techniques
to directly target the tumor(s). Our expert team including oncologists and interventional radiologists
decide on the mode of precision deployment for these customized medications, to maximize their benefits.
FDA Approved Drugs
Optimized for your cancer mutations.
Repurposed Drugs
Off-label use of approved medications.
Custom Compounded Adjuvants
Genetically typed for each patient.
At Envita, we understand that all patients with the same type and stage of tumor don’t respond
similarly to the same medications, because each patient’s genetics varies from the other. Our advanced and
in-depth genomic analysis of each patient helps us identify the FDA approved drugs and their specific dosage,
suitable for optimizing treatment efficacy in each individual patient.
This process of precision oncology takes the guesswork out of cancer treatment, as it
identifies the drugs which havethe best chances of treating your disease. Even these FDA approved drugs are
customized to a certain extent because we adjust the dosing to suit each patient’s individual biomarker and
pharmacogenetic information which is the way their body metabolizes the medicines. Not everyone metabolizes at the
same rate, so adjusting the dosage is crucial to reduce chances of toxicity while killing the cancer. Also, key
combinations minimize drug resistance and enhance the patient’s energy and quality of life throughout the
treatment process.
Even with the FDA fast track approval process for clinical trials in oncology, many targets do not yet have
approved drugs. Lack of appropriate drugs makes many patients fail standard care, especially in late stage and
complex cancers.The ability to custom-develop drugs for actionable targets, is one of the key hallmarks of
precision oncology. However, most patients do not even get access to precision oncology in standard care, and even
if they do, it is a watered-down form compared to Envita.
Our entire system is built to overcome these limitations found in almost every cancer hospital and center in the
country. Envita’s robust infrastructure is designed around precision, it is not a second thought, rather it is at
the core of helping our patients here.
Envita Precision Algorithm vs. Standard Oncology Precision Testing
Envita Medical Centers
Standard Oncology Precision Testing
RNA Transcriptome Genes
Envita Medical Centers:20,000+
Standard Oncology:Unchecked
SNV/CNV Genes
Envita Medical Centers:452
Standard Oncology:309
Rearrangements/Fusion Genes
Envita Medical Centers:51
Standard Oncology:27
Microsatellite Instability (MSI)
Envita Medical Centers:Checked
Standard Oncology:Checked
Tumor Mutation Burden (TMB)
Envita Medical Centers:Checked
Standard Oncology:Checked
BRCA 1/2
Envita Medical Centers:Checked
Standard Oncology:Checked
Immunohistochemistry
Envita Medical Centers:Checked
Standard Oncology:Unchecked
Chemosensitivity
Envita Medical Centers:Checked
Standard Oncology:Unchecked
Concurrent Liquid Biopsy
Envita Medical Centers:Checked
Standard Oncology:Unchecked
Exosomal miRNA Analysis
Envita Medical Centers:Checked
Standard Oncology:Unchecked
Circulating Tumor Cells Enumeration
Envita Medical Centers:Checked
Standard Oncology:Unchecked
Pharmacogenomics
Envita Medical Centers:Checked
Standard Oncology:Unchecked
Individualized Therapy Recommendation
Envita Medical Centers:Checked
Standard Oncology:Unchecked
Carcinogenic Exposure - Root Causes
Envita Medical Centers:Checked
Standard Oncology:Unchecked
Inflammation Markers
Envita Medical Centers:Checked
Standard Oncology:Unchecked
Metabolic Target Drivers
Envita Medical Centers:Checked
Standard Oncology:Unchecked
*Individual results may vary. Envita
makes no guarantees for outcomes.
To boost our patients’ holistic recovery and empower their immune system for better tackling the cancer, we work
to reduce toxicities caused by anti-cancer medications. Increased toxicity leads to a weakened immune system,
which further impacts your body’s ability to fight cancer relapse.
To minimize the side-effects of a weakened immune system during cancer treatment, we adjust the dosage of every
medicine for each patient’s specific metabolic rate which forms a strategic aspect of comprehensive cancer care.
Our detailed algorithms, developed over 20 years of clinical practice, give us an in-depth understanding of the
key relationships between medications and integrative agents, which may be the best optimal combinations for our
patients based on their testing.
Precision Dosage Regulation
To minimize the side-effects of a weakened immune system during cancer treatment, we adjust the dosage of
every medicine for each patient’s specific metabolic rate which forms a strategic aspect of comprehensive
cancer care.
Repurposed Drug
Repurposed drugs are FDA approved drugs which are used to treat a certain condition for which it is not labeled
or marketed. Off-label use of approved medications is known as repurposed drugs. For example, our extensive
genetic testing may show that an FDA approved drug for treating breast cancer will be effective in treating a
particular patient’s ovarian cancer, if this is discovered we go ahead and use the repurposed drug for treating
the patient because our ultra-analytes liquid biopsy has determined its efficacy.
Off-label use of drugs is common practice for doctors in every discipline, but pharmaceutical companies are not
allowed to market their drugs for any other condition, except for those approved by the FDA. At Envita, our
doctors prescribe off-label use of certain drugs only when a patient’s genetic and metabolic hallmarks of testing
reveals that their specific mutations and cancer drivers could be tackled by those drugs, while protecting their
healthy cells.
Custom Compounded Adjuvants
Adjuvants are add-on or supportive medications which play an important role in enhancing the efficacy of your
treatment. They comprise advanced phytotherapeutic medications, which are derived from natural agents like
extracts of plants andherbs. Several studies have shown how natural agents can help in cancer prevention and
treatment,so we utilize the latest findings from several published studies, including our own publications, to
custom compound adjuvants especially targeted for each patient’s specific cancer biomarkers. These biomarkers
include many analytes and combinations that are reviewed for each patient to maximize benefits of cancer treatment
and help restore health.*
Custom-compounding medicines play an important role on many levels in patient care. Over the years, we have seen
exceptional results with combinations that use integrative targets to help patients optimize response to care. It
is important to know that some of the best pharmaceutical medications came from plants or derivatives. Often,
these agents can be a critical support while minimizing toxicity and increasing mechanisms of tumor kill.
Adjuvants are supportive
medications which play an important role in enhancing the efficacy of your treatment.
Custom compounded adjuvants are designed to
target each patient’s specific cancer biomarkers.
* Smith, A.J., Oertle, J. and Prato, D. (2015) Multiple Actions of Curcumin
Including Anticancer, Anti-Inflammatory, Antimicrobial and Enhancement via Cyclodextrin. Journal of Cancer
Therapy, 6, 257-272.
* Smith, A., Oertle, J., Warren, D. and Prato, D. (2016) Quercetin: A
Promising Flavonoid with a Dynamic Ability to Treat Various Diseases, Infections, and Cancers. Journal of Cancer
Therapy, 7, 83-95.
The Right Mix for You
The goal of our treatment is to deliver a combination of all these types of medicines, which work together to
effectively heal your body. While certain elements of the medicines are targeted to achieve cancer kills, others
are meant to restore your immune system, so it is strong enough to fight the disease. Each of these different
types of medicines are custom-made and dosed for each individual patient with the aim of giving them the best
chance at life. Our custom drug design and proprietary delivery of the agents is what really sets Envita apart as
a world leader in precision integrative treatment for cancer.
Call Us Today
At Envita, our expert medical team, including oncologists, interventional radiologists, researchers, and
pharmacists, work relentlessly to attack your cancer from all possible sides. Our experience of 20 years treating
thousands of late-stage and complicated cancer cases, has shown that personalizing precision oncology treatments
may give patients a better chance of a holistic recovery. If you or your loved ones have any questions related to
cancer treatment, please feel free to call us at: 866-830-4576. God bless you on your journey to healing!
Our team is ready to help you get your life back! Please enter your contact information and a Patient Care
Expert will contact you shortly. If you would rather speak now, please give us a call at 1-866-830-4576.
