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Early, Late-Stage, and Metastatic Stomach Cancer Treatment
Advanced Gastric Carcinoma Treatments for Patients Needing
Precision Options
You shouldn’t have to surgically remove a part of your stomach or depend on a feeding tube to treat late-stage
stomach cancer. At Envita Medical Centers, a world-class Center of Excellence for Precision Oncology located in
Scottsdale, Arizona, we have been working on going beyond standard oncology care for gastric cancers and focus on
highly targeted treatment with your holistic recovery.
Based on our clinical experience of over 20 years treating late-stage and complex cancers, we use powerful
combinations of leading-edge conventional treatments and natural therapies, personalized to suit each patient’s
specific causative factors to help them respond to care.
Disclaimer: Individual results will vary. Envita makes no guarantees for outcomes. Each patient case is unique. Please
consult your doctor before making any changes to your medical treatment. Not every patient is a candidate for care or
achieves these results. Treatments used in this case may not all be FDA approved for the treatment of this condition.
We utilize precision-targeted therapies to treat not just stage 4 gastrointestinal stromal tumors, but all types of
cancers because precision oncology has the potential to take cancer care to the next level. Our proprietary
treatments,
such as, CIPI™ (Chemo Immuno Precision Injections), GTFC™ (Genetically Targeted Fractionated Chemotherapy), and
personalized immunotherapies, have proved beneficial for stomach cancer patients, many of whom were refractory to
standard treatment options.
Envita’s unique approach is designed to bring the latest developments in cancer research into clinical practice, as
we
work towards precision-targeting the disease while re-building the patient’s immune system. To target the unique set
of
causes responsible for disease growth and proliferation in each individual patient, we break away from the
one-size-fits-all protocols, typically utilized in most standard cancer treatment centers in the country.
Precision Care is Key to Check Disease Progression
Precision oncology helps doctors gain a better understanding of each patient’s individual cancer by identifying their
unique cancer drivers, responsible for the growth and spread of the diseases. However, according to the National
Comprehensive Cancer Network (NCCN) guidelines, typically followed by major cancer centers and hospitals, patients are
allowed access to precision oncology only as a follow-up to failed first-line treatments.
The first-line treatments are based on tumor type and cancer stage, which may not be enough to check diseases
progression in all stomach (gastric) cancer patients. This lack of precision care explains why all stomach cancer
patients with the same type and stage of disease do not respond similarly to the same treatment.
At Envita, Precision Oncology is the foundation of each patient’s unique
treatment plan!
The limited few who get access to precision care as per the NCCN guidelines, receive a watered-down version of
Envita’s
detailed precision algorithms. We go beyond basic genetic testing to analyze many more parameters, such as epigenetic
alterations, molecular pathways, and messaging, which could play a role in each patient’s distinctive stomach
(gastric)
cancer.
The earlier you get access to Envita’s detailed Precision Algorithms,
the better are your chances of a long-term
remission!
Envita Precision Algorithm vs. Standard Oncology Precision Testing
Envita Medical Centers
Standard Oncology Precision Testing
RNA Transcriptome Genes
Envita Medical Centers:20,000+
Standard Oncology:Unchecked
SNV/CNV Genes
Envita Medical Centers:452
Standard Oncology:309
Rearrangements/Fusion Genes
Envita Medical Centers:51
Standard Oncology:27
Microsatellite Instability (MSI)
Envita Medical Centers:Checked
Standard Oncology:Checked
Tumor Mutation Burden (TMB)
Envita Medical Centers:Checked
Standard Oncology:Checked
BRCA 1/2
Envita Medical Centers:Checked
Standard Oncology:Checked
Immunohistochemistry
Envita Medical Centers:Checked
Standard Oncology:Unchecked
Chemosensitivity
Envita Medical Centers:Checked
Standard Oncology:Unchecked
Concurrent Liquid Biopsy
Envita Medical Centers:Checked
Standard Oncology:Unchecked
Exosomal miRNA Analysis
Envita Medical Centers:Checked
Standard Oncology:Unchecked
Circulating Tumor Cells Enumeration
Envita Medical Centers:Checked
Standard Oncology:Unchecked
Pharmacogenomics
Envita Medical Centers:Checked
Standard Oncology:Unchecked
Individualized Therapy Recommendation
Envita Medical Centers:Checked
Standard Oncology:Unchecked
Carcinogenic Exposure - Root Causes
Envita Medical Centers:Checked
Standard Oncology:Unchecked
Inflammation Markers
Envita Medical Centers:Checked
Standard Oncology:Unchecked
Metabolic Target Drivers
Envita Medical Centers:Checked
Standard Oncology:Unchecked
*Individual results may vary. Envita
makes no guarantees for outcomes.
Medical studies show how the heterogeneity of gastric cancer is mainly linked to genetic and epigenetic alterations
[1],
which is why Envita’s detailed precision oncology extensively examines all these parameters of each individual
patient.
This in-depth analysis widens the scope of personalized precision oncology treatment options, making it more effective
for each individual patient’s unique gastric cancer expressions. Utilizing the new treatments in personalized
precision
oncology potentially helps in reducing chances of drug resistance, which often leads to further diseases complications
and metastasis.
Treatment Focused on Your Unique Stomach Cancer Presentation
Unlike clinical trials where patients are directed as a last resort in the hopes of a singular new drug discovery to
help them, we build a personalized medical blueprint to target each patient’s specific stomach cancer expressions. We
go
beyond the standard treatments, such as gastrectomy, untargeted chemotherapy, and radiation, with our advanced
precision
algorithms. This personalized precision oncology approach targets each patient’s individual cancer, rather than going
by
a one-size-fits-all approach based on cancer type and stage.
In our clinical opinion, personalized precision targeted treatments may aid to curb the high metastatic nature of
gastric cancer. Checking metastasis is a crucial aspect of treatment in both early as well as late-stage stomach
cancer
because metastasis is responsible for 90 percent of cancer deaths [2].
Stomach cancer, also known as gastric cancer, is one of the most prevalent forms of cancer globally, with more
than 1
million people newly diagnosed worldwide each year.*
*Thrift, A. P., & El-Serag, H. B. (march 2020). Burden of Gastric Cancer
[Abstract]. Clinical Gastroenterology and
Hepatology. doi:https://doi.org/10.1016/j.cgh.2019.07.045
*Riihimäki M, Hemminki A, Sundquist K, Sundquist J, Hemminki K. Metastatic
spread
in patients with gastric cancer.
Oncotarget. 2016;7(32):52307-52316. doi:10.18632/oncotarget.10740
Treat the Cause to Reduce Chances of Metastasis
Cancer is a disease of genetic mutations triggered by many causative factors which can be genetic, environmental, and
infectious. If these mutations are not checked, the cancer can metastasize or spread to different parts of the body.
Identifying and treating the complex connections between these factors and gastric cancer can be key to
comprehensively
addressing a patient’s unique gastric cancer presentation and reducing the chance of metastasis.
Undiscovered metastatic cells in the early stage of disease can lead to advanced stages of gastric cancer if not
addressed properly. Further metastasis in the later stages can spread cancer cells that are resistant or unresponsive
to
drugs, so avoiding metastasis should be a critical component of a comprehensive cancer treatment plan.
Personalized Precision Oncology for Holistic Recovery
To overcome the challenge of metastasis, Envita personalizes your treatment plan, which is focused on improving your
quality of life, increasing longevity, and reducing toxicity. Our four-pillared approach is designed to attack your
specific cancer biomarkers from all possible angles, giving you a better chance at healing. Biomarkers are attributes
of
cancer cells containing specific chemotherapy and immunotherapy targets.
Step 1
Genomic Identification Unravels Your Cancer Cause
At Envita, we see many patients whose previous treatments such as chemotherapy, surgery, radiation, and basic
immunotherapy options like PD-1 inhibitors have failed due to the lack of receiving a proper genomic analysis to
identify what is feeding the cancer. Knowing the cause of your specific stomach cancer is critical for designing a
precision-targeted treatment plan based on your genetic needs which helps to enhance tumor kill as well as equip your
immune system to better find and attack cancer.
Causative Factors Correlated with Gastric Cancer
Helicobacter pylori (H.
pylori) infection of the stomach
PDQ® Adult Treatment Editorial Board. PDQ Gastric Cancer Treatment. Bethesda,
MD:
National Cancer Institute.
Available at: https://www.cancer.gov/types/stomach/patient/stomach-treatment-pdq. Accessed 09/02/2020. [PMID:
26389328]
One of the most common causes for stomach cancer has been found to be the Helicobacter pylori bacterial
infection
[3].
Research has shown that the H. pylori bacteria offers two pathways for stomach cancer development: directly by
inducing
mutations within gastric epithelial cells found in the mucosal lining of the stomach, and indirectly through
inflammation of the gastric epithelial cells, which is gastritis [4].
H. pylori infections directly cause gastric cancer through oncoproteins, a
protein generated from mutated genes,
which
trigger tumor growth and proliferation. These oncoproteins disrupt intercellular junctions, disturb cellular
polarity,
increase growth factors, and inhibit apoptosis, which is natural cell death.
Also, H. pylori infection indirectly contributes to gastric cancer by inducing the innate immune system to
recruit
inflammatory cells, which triggers inflammation. This increase in inflammation can further damage the cells of
the
stomach and stimulate the growth of tumors.
All the different causative factors can play an important role in the
mutational
acceleration of
gastric cancer and can
even impact drug resistance. These factors also affect immune reactivity towards the cancer by often
downregulating the
body’s own defense against cancer. Identifying the exact causative factors through an extensive genomic
analysis helps
in pinpointing your specific cancer trigger, which is crucial for determining your personalized treatment
plan.
All the different causative factors can play an important role in the mutational
acceleration
of gastric cancer and
can
even impact drug resistance. These factors also affect immune reactivity towards the cancer by often downregulating
the
body’s own defense against cancer. Identifying the exact causative factors through an extensive genomic analysis helps
in pinpointing your specific cancer trigger, which is crucial for determining your personalized treatment plan.
Fortunately, Envita is not just a Center of Excellence for Precision Oncology but also for Chronic Disease. Our
clinical
experience in treating chronic infectious diseases gives our physicians an intimate knowledge into how these
infections
can be contributing to the cancer’s continued spread, if not properly diagnosed and addressed with precision medicine.
Envita is comprehensively experienced in treating resistant and persistent chronic infections in addition to cancer.
We
have published extensive research detailing our findings which connect cancer types to specific viral, fungal, and
bacterial infections [5]. Treating the root cause of stomach cancer, in addition to attacking cancer directly, is a
priority at Envita Medical Centers.
Immuno Targeting Helps Minimize Risk of Metastasis
The immune system is key in treating both cancer and chronic infections. Often, the patients who come to
Envita with
stomach cancer have severely compromised immune systems. Previously failed untargeted chemotherapy treatments and
undiagnosed chronic infections are known to deplete the immune system. Envita has even seen the wrong choice in
chemotherapy lead to increased metastasis of stomach cancer, so we focus on immuno targeting and immune system
reactivation to bolster your immune system and help minimize the risk of metastasis. We go far beyond basic
immunotherapy drugs, such as check point inhibitors, to provide much more in-depth immunotherapy programs for our
patients.
Envita’s Ultra Analytes Liquid Biopsy is deployed to identify targeted
immunotherapy options to help get
your immune system working properly again.
Through our Ultra Analytes Liquid Biopsy, we establish the chemo and immuno targets for your specific
stomach cancer
expressions. The liquid biopsy analyzes the most recent mutations in your cancer, by examining the Circulating Tumor
Cells (CTCs) collected from your blood sample and cancer associated cells. The CTCs are tiny particles which break
away
from a growing tumor and enter your blood stream, so investigating these particles carrying the fresh cancer mutations
help us precision-target your unique cancer and proactively treat it before it metastasizes.
Disclaimer: Individual results will vary. Envita makes no guarantees for outcomes. Each patient case is unique. Please
consult your doctor before making any changes to your medical treatment. Not every patient is a candidate for care or
achieves these results. Treatments used in this case may not all be FDA approved for the treatment of this condition.
Step 3
Personalized Drug Design to Target Your Specific Stomach Cancer
We custom-build the medications your stomach cancer is most likely to respond to at our in-house pharmacy
based on the findings of our in-depth genomic analysis. In our clinical experience, a combination of FDA
approved drugs, repurposed drugs, and custom-compounded adjuvants, optimize the goal of improving tumor kill,
while strengthening your immune system. This process of personalizing the drugs gives our patients the
much-needed advantage.
FDA Approved Drugs
Optimized for your cancer mutations.
Repurposed Drugs
Off-label use of approved medications
Custom Compounded Adjuvants
Genetically typed for each patient.
Our detailed testing helps establish the actionable targets for your specific cancer, enabling
us to
take the
guesswork
out of your treatment and choose the most suitable FDA approved and repurposed drugs for your care. The drug dosage is
adjusted to suit each patient’s individual rate of metabolism allowing the medicines to enhance tumor kill without
causing toxicity in your body.
Some of the custom-compounded adjuvant therapies may also include genomic targeted phytotherapeutic
adjuvant agents
derived from plant extracts and herbs. Precision adjunctive care is designed to stimulate your immune system,
rebuilding
it to serve as the body’s best defense against cancer.
Adjuvant therapies are
genetically typed to
target each
patient’s individual
stomach cancer and are crucial for
maximizing the benefits of your treatment.
A healthy immune system recognizes and terminates thousands of cancer cells daily. By using our
personalized
custom-compounded adjuvants, we modulate the gene expressions of your specific stomach cancer cells to reactivate the
body’s natural defense against cancer.
Choosing a suitable mode of precision deployment enhances the impact of the treatment. Envita Medical Centers has
developed a host of proprietary mechanisms for deploying chemotherapy and immunotherapy agents. These precision
deployment mechanisms aim to increase the bioavailability of personalized anti-cancer medicines, so they produce
the
desired effect without weakening your immune system. Our doctors decide on the best mode of precision-deployment based
on your specific stomach cancer presentation.
Envita’s GTFC™ precision-deployment procedure genetically targets the most advantageous chemotherapy options for a
patient's unique stomach cancer presentation. Each cancer can present a unique combination of genetic, environmental,
and infectious factors that require a personalized approach of treatment. GTFC™ is driven by advanced genetic testing
and
proprietary treatment algorithms which guide our expert physicians in building protocols to individually target and
attack a patient’s unique gastric cancer’s biomarkers.
The combination of genetically determined chemotherapies and adjuvant agents is delivered intravenously through
precision-based micro-dosages, allowing for better absorption of the medication into the cancerous cells. This
approach
of delivering low dose, but precision-targeted chemotherapy, reduces the risk of damage to healthy cells. With the
healthy cells remaining intact, GTFC™ potentially increases effectiveness of medications while minimizing the negative
side-effects such as weakened immunity which patients may experience from untargeted chemotherapy.
Disclaimer: Individual results will vary. Envita makes no guarantees for outcomes. Each patient case is unique. Please
consult your doctor before making any changes to your medical treatment. Not every patient is a candidate for care or
achieves these results. Treatments used in this case may not all be FDA approved for the treatment of this condition.
With GTFC™, most of our patients experience little to no side-effects, allowing them to remain active during
treatment.
Some cancer patients at Envita have even been able to go to the gym and hike during their treatment at Envita.
Chemo Immuno Precision Injections or CIPI™ is Envita’s proprietary form of tumor chemoembolization that is performed
through advanced interventional radiology. Compared with traditional treatment alone, interventional oncology
targeting
can greatly improve the recovery of gastric cancer patients after chemotherapy, reduce the occurrence of complications
and inflammation, and improve the survival rate of patients [6].
In standard cancer centers, commonly used procedures to treat stomach cancer are gastrectomy or a partial
gastrectomy.
These surgeries are done to remove the cancerous portion of the stomach, but CIPI™ takes targeting to entirely new
level
with precision drug design and delivery straight to the tumor using a small catheter the size of hair shaft. In this
uniquely targeted approach, patient-specific chemo and immuno agents are pushed through the catheter, directly to the
tumor where the agents are sealed inside the tumor to destroy it from the inside-out.
Unlike surgeries, the CIPI™ procedure potentially increases tumor kill and creates systemic immunotherapy response
throughout the body to treat metastasis while simultaneously working to reduce the many negative side-effects
associated
with untargeted chemotherapy programs. CIPI™ is a great alternative to invasive surgery, as it is a minimally invasive
approach to treat the difficult to reach gastric tumors and it does not even require hospital stay.
There are several types of stomach cancer, which are classified based on the cells in which the cancer originates.
The
following are some of the different types of stomach cancer:
Gastric Adenocarcinoma: This is the most common type of stomach cancer, accounting for approximately
90-95% of cases. Adenocarcinoma originates
in the glandular cells that line the stomach and produce mucus and digestive enzymes.
Lymphoma: Lymphoma is a cancer that begins in the lymphatic tissue. It can occasionally develop in the
stomach and is referred to
as primary gastric lymphoma. This type of stomach cancer is relatively rare.
Gastrointestinal stromal tumor (GIST): GISTs are rare tumors that can develop in the stomach, as well as
in other parts of the digestive system. GISTs
originate in the specialized cells of the digestive tract, which are involved in regulating muscle contractions.
Carcinoid tumor: Carcinoid tumors are a type of neuroendocrine tumor that can develop in various organs,
including the stomach. These
tumors originate in the hormone-producing cells of the stomach lining.
Other rare types of stomach cancers: Squamous Cell Carcinoma, Small Cell Carcinoma, Undifferentiated
Carcinoma, and certain soft tissue sarcomas, like
leiomyosarcomas may also originate in the stomach.
Call us today to find out about your personalized precision oncology treatment options for stomach
cancer. Our expert
team including oncologists, interventional radiologists, researchers, and pharmacists, undergo extensive training to
adapt themselves to our unique precision oncology approach. If you or your loved ones have any questions regarding
stomach cancer, please reach out to us at: 866-830-4576. May God bless you on your journey to healing.
[1] Bonelli P, Borrelli A, Tuccillo FM, Silvestro L, Palaia R, Buonaguro FM. Precision medicine in gastric
cancer. World J
Gastrointest Oncol. 2019;11(10):804-829. doi:10.4251/wjgo.v11.i10.804
[2] Seyfried TN, Huysentruyt LC. On the origin of cancer metastasis. Crit Rev Oncog. 2013;18(1-2):43-73.
doi:10.1615/critrevoncog.v18.i1-2.40
[3] American Cancer Society. What Causes Stomach Cancer? 2020 12/14/2017 [cited 2020 9/3/2020]; Available
from: https://www.cancer.org/cancer/stomach-cancer/causes-risks-prevention/what-causes.html.
[4] Watanabe, T.C.H.M.H.S.N. Mechanism for Gastric Cancer Development by Helicobacter pylori Infection. 2008
[cited 2020;
Available from: https://www.medscape.com/viewarticle/579410_2
[5] Smith, A. , Oertle, J. and Prato, D. (2014) Cancer and Infectious Causes. Open Journal of Medical
Microbiology, 4,
161-177. doi: 10.4236/ojmm.2014.43019.
[6] Wu P, Wang J. Efficacy of interventional therapy and effect on inflammatory factors in patients with gastric
cancer
after chemotherapy. Oncol Lett. 2019;18(2):1733-1744. doi:10.3892/ol.2019.10505
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607250/
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