Ozone therapy has been marred by conventional science for years due to many flawed experimental
designs or small sample sizes of the population in which it intends to study. For this reason,
many physicians have dismissed ozone therapy and limited funds have been delegated to furthering
the knowledge of its therapeutic effects. However, there is evidence that suggests that ozone
does have various therapeutic effects that range from disinfection of pathogens, anticancer
properties, and treatment of back ailments. In this paper, we have collected the more promising
studies that suggest the efficacy and safety of ozone therapy primarily focusing on
autohemotherapy. This paper is designed to promote awareness of ozone therapy and to show some
supporting evidence of its efficacy. Clinically, ozone therapy is often used adjunctively and
combined with other treatment modalities to enhance or encourage a desired mechanism of action.
Since the efficacy of ozone alone is still contentious, it is important to note that ozone
therapy should be used in conjunction with other various treatments with very few exceptions.