Ovarian cancer is a difficult and trying disease; with a 47% five-year survival rate(1), more than half of
those treated by conventional oncology will not respond. Furthermore, those patients who do enter remission are likely
to be faced with a recurrent and persistent form of cancer that, in our experience, standardized protocols are not
properly equipped to combat. With almost 2 decades of experience, it is our clinical opinion that many patients are
led down the wrong path when beginning their ovarian cancer care. Instead of the one size fit all method that is
currently practiced, care should be based on understanding what defines your particular cancer and treatment should be
personalized to each and every patient. Envita Medical Centers is an integrative center of excellence for personalized
oncology and has unique testing and treatment options that may help ovarian cancer patients respond more favorably to
care and potentially improve outcomes to increase the patient's overall quality of life. The sooner we can deploy
targeted treatment the better.
Envita Medical Centers doesn't make any guarantee of outcomes. Results are not typical and will vary from
person to person and should not be expected.
At Envita Medical Centers, we have extensive experience in treating recurrent and persistent ovarian cancer that has
become resistant to traditional treatment options. We specialize in difficult to treat cancers and have a unique
understanding of integrative treatment options that need to be considered when traditional cancer options have failed.
By combining the latest in research-based natural and conventional medicine from around the world, we have developed
proprietary techniques and treatments to give our patients the best chance to respond positively to care.
Precision Genetic Testing for Ovarian Cancer
Envita works with the most advanced laboratories from around the world to develop state-of-the-art testing for our
patients. This world-class testing is used to precisely build and direct personalized cutting-edge ovarian cancer
treatments and therapies to combat the most difficult cancer diagnoses like no other clinic in the nation can. It is
important to realize that your ovarian cancer is unique, it is constantly mutating and changing to fight against
treatment options that may be thrown at it. To fight back we need to aim at where your cancer is going rather than
where it has been, and precision testing is the key to achieving progress. Not all genetic testing is the same though,
what we do at Envita is far beyond what most other clinics can offer in the realm of genomics and even targeted
integrative treatments.
Envita Medical Centers doesn't make any guarantee of outcomes. Results are not typical and will vary from
person to person and should not be expected.
Most cancer centers that do genetic testing are basing their results on old tissue biopsy data. Because the cancer is
constantly mutating the genetic information acquired from a tissue biopsy is not an accurate representation of the
genetic targets the cancer is currently presenting. Additionally, the genetic testing results achieved through
traditional tissue biopsy provides minimal information and does little to influence the conventional static approach
being used to treat late-stage ovarian cancer.
Envita’s treatment methodology is based on the in-depth genetic information we gather on you and your unique cancer
mutations. We look at genetic information from your circulating cancer cells that represent the most recent forms of
your cancer and use them to determine biomarkers, chemotherapy susceptibility, molecular profiles, level of mutation,
treatment resistance, and immunotherapy targets. In addition, we continue testing to track your circulating cancer
cells and pivot our treatment to be completely dynamic, changing and adapting it to your most recent ovarian cancer
mutations. This information is the backbone of how we treat your cancer and is part of what makes our approach more
advanced than what other clinics provide.
No other clinic in the nation can test and treat at the personalized in-depth level we do, this gives us a decided
edge on treating your cancer on multiple levels potentially allowing for the best chance at positive outcomes. The
information we gather will be essential for fighting your circulating ovarian cancer cells and building a
multitargeted, multifaceted treatment protocol. We take a detailed look at the genetics of your circulating ovarian
cancer cells to identify genetic targets and chemotherapy-susceptibility to design medications at our in-house custom
pharmacy that are best suited to target your specific needs. We call this method “N of 1” treatment and it means that
our protocols are one of a kind, designed to treat your specific cancer with custom testing and individualized
treatments.
However, we are not only interested in treating the cancer cells. We also want to do extensive testing to map your
genetics, epigenetics, and miRNA in addition to testing for heavy metals, toxins, and infections to treat the root
cause of your ovarian cancer and provide a complete approach to combating your disease.
Envita’s Ovarian Cancer Immunotherapy Options
The immune system is an important weapon against cancer and by treating your immune system through detoxification,
nutrition, and immunotherapy we can help your body combat your condition in addition to helping you heal and recover.
Information we gather in the testing stage like biomarkers, toxin levels, and nutritional data will help us in
creating customized medications of the highest quality and safety at our in-house custom compounding pharmacy. Most
oncology groups provide only commercially available drugs and are not able to customize medications in the way we need
to treat our patients. For this reason, we developed our own pharmacy to facilitate our personalized targeted
treatments and to ensure the quality and safety of our targeted medications. The information we gather through testing
allows us to develop immunotherapy options designed with the goal of helping rebuild and train your immune system to
target your cancer.
Envita Medical Centers doesn't make any guarantee of outcomes. Results are not typical and will vary from
person to person and should not be expected.
Through immunotherapy, we aim to promote the immune system to fight your ovarian cancer and attack the disease on
multiple levels. Though immunotherapies such as PD1 inhibitors have been helpful in treating ovarian cancer it is
often not enough. There are other important immunotherapies that must be considered. At its international division,
Envita implores many forms of immunotherapy to aid in treatment. One technique called IMX Therapy involves the
utilization of expanded natural killer and dendric cells to use the body’s natural defensive to combat your ovarian
cancer. Your natural killer and dendric cells are genomically reprogramed to identify cancer cells and mark them for
immune response(2). Testing is used to identify the surface biomarkers of your circulating cancer cells and
dendritic cells can be removed, modulated, and replicated for reintroduction into the body(2). From there
these modified dendritic cells can identify and mark cancer cells for attack by the immune system(2). This
is only one of the many cutting-edge immunotherapies we employ at Envita. Actively addressing the immune system and
directly treating your cancer is important for providing long-term results. However, directly treating your ovarian
cancer is not the only way to combat your disease. Refer to our published paper Immunotherapy in Cancer Treatment to
learn more. (IMX Therapy has not been reviewed or approved by the FDA and is currently only available at our Envita
Mexico facility)
Treating the Causes of Ovarian Cancer
Treating the root cause of your cancer is also a key component to the multifaceted approach we use at Envita. One
possible cause of cancer is genetic. Genetic mutations are commonly linked to ovarian cancer and mutations in the BRCA
1 and BRCA 2 genes have been found to be a high-risk factor for both ovarian and breast cancer(3). The BRCA
genes are important because they are responsible for suppressing tumor growth and when they become mutated cancer risk
is significantly increased. It is estimated that about 1.3% of the general population of women will develop ovarian
cancer in their lifetime(3). However, about 44% of women with a mutation of the BRCA 1 gene will be
expected to develop ovarian cancer and about 17% of those with a mutation of the BRCA 2 gene will be expected to
develop ovarian cancer in their lifetime(3). BRCA is a very important gene when focusing on ovarian cancer
but there are many more genes that can be identified as potential treatment targets.
Envita’s genetic testing is far more advanced and in-depth than what other major clinics and hospitals offer. We look
at multiple genes including BRCA when identifying important targets and treating our ovarian cancer patients. We
accomplish this by using state-of-the-art epigenetic and miRNA therapies to address the genetic factors that may be
feeding the cancer. With epigenetic information, we can design medications in our customizable pharmacy with the goal
to promote the expression of tumor suppressant genes like BRCA 1 and 2 and block oncogenes that facilitate tumor
growth. We have gained extensive experience treating the genetic causes of cancer in our 20 years as a medical clinic
and we understand the importance of addressing this problem to promote your healing.
These epigenetic targets and genetic mutations are discovered through our extensive testing, along with other
potential causes for your ovarian cancer including environmental causes like heavy metals and toxins, and infectious
causes like bacteria and viruses. Research has shown that hereditary genetic factors largely affect ovarian cancer,
but in general, only 2-3% of cancer is caused by genetic factors(4). However, 98% of cancers develop from
carcinogens that cause cancer genes to turn on epigenetic factors. Refer to our peer-reviewed published paper Cancer
and Infectious Causes to learn more. We are experts at treating infections and our proprietary testing will help
determine if there are infectious or environmental causes linked to your ovarian cancer. More often than not, we find
these factors during testing with our patients.
Once all of the potential causes we are aware of that may be linked to your cancer have been determined, we then
utilize personalized treatment options to include specific detoxification treatments to aid your body in removing
toxins, heavy metals, and other carcinogens to include chemotherapy that extends past its half-life. Traditional detox
methods can be helpful but when treating ovarian cancer; what Envita offers goes far beyond what other clinics are
able to provide. We utilize unique detoxification technology which can filter 4.5 times your blood volume within about
an hour through special cartridges that remove toxins, chemicals, circulating tumor cells, and infectious die-off
before circulating the blood back into your body. We have seen clinically this advanced form of detoxification provide
beneficial results for most patients during treatment; where traditional detoxification methods can take months or
even years to be effective and still not achieve this level of detox. Identifying and treating the root causes of your
ovarian cancer is an often-overlooked factor yet critical factor that Envita addresses to help our patients outperform
other centers in our clinical opinion.
Going Beyond Traditional Chemotherapy for Ovarian Cancer
Much like how we approach the other areas of ovarian cancer treatment, we approach chemotherapy in a personalized
targeted methodology that utilizes cutting-edge proprietary therapies with metronomic dosing. Standard oncology uses
maximum therapeutic doses to try and choke out your cancer; cancer centers use the maximum therapeutic doses in most
cases without accurate genetic targeting. Most of our patients have exhausted these measures and found it to be a
harmful and taxing approach that causes a multitude of side-effects and is extremely hard for their body to tolerate,
possibly harming more than it helps if the wrong chemotherapy agents are selected. When the wrong chemotherapy agents
are selected it allows the cancer to become even more resistant leading to further spread and weakens the immune
system overall. This is when most patients get a wake-up call and look for more personalized approaches.
Envita Medical Centers doesn't make any guarantee of outcomes. Results are not typical and will vary from
person to person and should not be expected.
At Envita we use a specialized targeted treatment that was researched and developed by our physicians known as
Genetically Targeted Fractionated Chemotherapy (GTFC). GTFC is designed with the goal of being more efficient at
treating real-time genetic targets of the cancer while reducing major side-effects and sparing and even improving the
immune system. GTFC is unique because it can increase the amount of chemotherapy medication absorbed by cancerous
cells. Often time only 4-5% of systemic chemotherapy makes it to the tumor while Envita works for 100% delivery direct
to the tumor with both intra-tumor deployment when needed and metronomic (low-dose) treatment coordinated.
To break it down we start with genetically targeted, this means we look at the genetics from your current circulating
tumor cells and free-floating DNA found in the circulation of your blood and tumor biopsy to target your cancer’s weak
points(5). We then gather information on biomarkers at a cellular, chromosomal, genetic, epigenetic,
antigen, and metabolic level. Then, multi-drug resistance, chemo susceptibility, and molecular profiles of your
ovarian cancer are taken into consideration to build a genetically targeted and fractionated chemotherapy protocol
that is designed to best attack and kill your unique form of cancer(5). In addition to genetically
targeting our chemotherapies, GTFC allows us to use many different types of chemotherapy at once at fractionated doses
and higher frequency(5). The fractionated part of our GTFC treatment is what makes this possible. By using
small doses of chemotherapy we can utilize multiple different drugs at once to attack your cancer from multiple angles
utilizing different methods of tumor kill while lowering the chances of the cancer cells being able to resist
treatment. Furthermore, by fractionating the doses of chemotherapy, we are able to dose at a higher frequency
providing a more consistent and comprehensive attack on your ovarian cancer(5). Finally, by utilizing
fractionated doses and combining it with pharmacogenomics (how your metabolizes drugs) and our advanced detoxification
methods the side-effects of GTFC can be vastly reduced in comparison to normal oncology(5). (refer to our
published paper Genetically Targeted Fractionated
Chemotherapy to learn more).
CIPI™, or CIPI™, or Chemo
Immunotherapy Percutaneous Injections, is one of Envita’s proprietary ovarian cancer treatment options that
takes full advantage of the targeted low-dose chemotherapy paradigm. CIPI™ is a unique form of chemoembolization
that directly targets the tumor cite for precision delivery of custom-tailored chemotherapy cocktails combined
with personalized immunotherapy adjuvant care. Working in concert, patient-specific micro-dosed chemotherapy and
genetically targeted adjunctive immunotherapy attack the tumor site while potentially minimizing the
detrimental sides-effects to the surrounding tissue. This is a game-changer, especially for ovarian cancer patients
who may have been unresponsive to conventional standard of care chemotherapy administration. Not all patients are
candidates for the CIPI™ procedure, so be sure to consult with Envita physicians
to see if CIPI™ is right for you.
This video is for informational purposes only. Individual results will vary. Envita makes no guarantees.
Consult with your doctor to see if CIPI™ is right for you. Not every patient is a candidate for Chemo
Immunotherapy Percutaneous Injection. Some cancers may not have actionable biomarkers or molecular profiles.
Do not alter your medical care based on any information provided in this video. Please, consult your doctor
prior to changing or stopping any current medical treatment you are receiving.
You may be wondering, how is Envita able to use such small doses of genetically target chemotherapies while
conventional oncology must use a maximum therapeutic dose? The question has many answers. To start, conventional
oncology often prescribes chemotherapy based on NCCN guidelines. The NCCN (National Comprehensive Cancer Network)
derives “effective” cancer treatment options based off large generic clinical trials that are based around a cancer
type and staging and do not take into account the patient’s genetic mutations. Envita, being a truly integrative
clinic, is not bound by the NCCN restrictions and are able to treat you, the patient, as an individual with unique
mutations and tailored treatment options. Our patients are “N of 1” meaning we build a personalized clinical treatment
for you and you alone based on your own genetic mutations and treatment options that may be effective based on your
specific ovarian cancer targets.
With all the research and development Envita does to customize and tailor our treatment options, it becomes clear
that Envita is in a league of its own. Based on our own patients' statements over the years and our clinical opinion,
Envita operates at a higher personalized integrative level and we offer one-of-a-kind personalized integrative
treatment options with unmatched care and compassion. Our philosophy is to provide the highest quality compassionate
care to our patients and to help them make meaningful and life-changing progress in the fight against their disease.
If you or one of your loved have questions about ovarian cancer, please contact our Patient Care Coordinator team at
1-866-830-4576 and let us help you on your path to treatment. And may God bless you on your journey
to healing.
References
[1] ACS. Survival Rates for Ovarian Cancer, by Stage. 2018 April 11, 2018 [cited 2018 11/9]; Available from:
https://www.cancer.org/cancer/ovarian-cancer/detection-diagnosis-staging/survival-rates.html.
[2] Smith, A.J., J. Oertle, and D. Prato, Immunotherapy in Cancer Treatment. Open Journal of Medical
Microbiology, 2014. Vol.04No.03: p. 14.
[3] NCI. BRCA Mutations: Cancer Risk and Genetic Testing. 2016 [cited 2018 11/9]; Available from:
https://www.cancer.gov/about-cancer/causes-prevention/genetics/brca-fact-sheet.
[4] Smith, A.J., J. Oertle, and D. Prato, Cancer and Infectious Causes. Open Journal of Medical Microbiology,
2014. Vol.04No.03: p. 17.
[5] Smith, A.J., J. Oertle, and D. Prato, Genetically Targeted Fractionated Chemotherapy. Journal of Cancer
Therapy, 2015. Vol.06No.02: p. 17.
