Early, Late-Stage, and Metastatic Liver (Hepatic) Cancer Treatment Options

Helping Patients Overcome Liver (Hepatic) Cancer with Personalized Precision Treatment Options

If you have an early or late-stage liver cancer diagnosis, you should know that you have found the right place because our unique and powerful personalized precision treatment approaches have helped thousands of patients, even those with inoperable liver tumors.

For the last 20 years at Envita Medical Centers, a world-class integrative center for Precision Oncology, our proprietary new treatments have been revolutionizing the cancer world with personalized targeted therapies and advanced immunotherapies.

Irrespective of the stage or type of cancer, we combine our genetically driven treatment approach with targeted immunotherapies to not only uproot the disease, but also to improve the overall health of the patient. Our oncologists take liver cancer treatment to the next level by integrating the latest in conventional medicine with research-based natural therapies, which have proved effective in both late as well as early-stages of liver cancer.

Disclaimer: Individual results will vary. Envita makes no guarantees for outcomes. Each patient case is unique. Please consult your doctor before making any changes to your medical treatment. Not every patient is a candidate for care or achieves these results. Treatments used in this case may not all be FDA approved for the treatment of this condition.

This article covers basic facts about liver cancer, including:

Difference Between Liver Cancer and Liver Metastases

Liver Cancer / Primary Liver Cancer
Cancer originating in the liver
May spread to surrounding blood vessels, lymph nodes, and other near or distant parts of the body, causing metastatic liver cancer
Less common than secondary liver cancer
Liver Metastases / Secondary Liver Cancer
Cancer originating in any part of the body, other than the liver but has spread to the liver
Generally, cancer originating in the pancreas, colorectal region, or stomach, may spread to the liver
More common than primary liver cancer

How Does Envita Go Beyond Standard Liver Cancer Treatments?

Our advanced integrative treatment approach gives us the liberty to break away from the standard NCCN (National Comprehensive Cancer Network) guidelines, which dictate treatment at all major cancer hospitals.

At Envita, we bring the latest developments in cancer research from around the world to help our patients recover holistically. Our personalized treatments go beyond these one-size-fits-all protocols determined by the type and disease staging system, to impact the cancer drivers of each individual patient. This customized approach may reduce chances of recurrence or metastasis, leading to long-term remissions.

Standard treatment of liver cancer generally includes partial hepatectomy, also called liver resection to surgically remove cancerous tumors, liver transplant, ablations, chemoembolization, radioembolization, chemotherapies, or radiation therapies. However, these standard treatments may not be effective enough, underlining the reason behind liver cancer being the sixth leading cause of cancer deaths in the United States. Despite advances in prevention techniques, screening, and new technologies in both diagnosis and treatment, incidence and mortality continue to rise.

According to the American Cancer Society’s report based on patient outcomes across standard cancer centers, which typically follow the NCCN guidelines, the 5-year relative survival rate of liver cancer is 20% which drops to a dismal 3% when the disease spreads to distant parts of the body.

To counter these statistics, we personalize the treatment plan for each individual patient helping them progress towards a disease-free survival. Our personalized treatments help to reduce chances of disease recurrence or spread to other parts of the liver in the early stages, while in late stages our treatments may arrest further spread to distant parts of the body and help patients respond better to care.

Personalized Treatment Options May Work Better Than Clinical Trials

Envita Medical Centers’ personalized precision oncology treatments may be a better option than clinical trials, because we custom-build treatment plans based on each patient’s unique liver cancer biomarkers.

Biomarkers may be proteins, enzymes, any other substances, or processes, which are indicative of the presence of cancer in the body. At Envita, we aim to affect the unique set of biomarkers causing each patient’s individual liver cancer, which helps in treating the disease at its core while improving the patient’s liver function and their general health.

Cancer is a disease of genetic mutations, and genetics differ from person to person, which highlights the need for personalization in cancer care.
Dr. Dino Prato NMD
Founder/CEO Envita Medical Centers

Common Types of Liver Cancer

As described by the National Cancer Institute, based on the cellular origin of the disease, liver cancer is commonly categorized into:

  • Hepatocellular carcinoma (HCC)- accounts for more than 80% of primary liver cancers
  • Fibrolamellar variant of HCC
  • Cholangiocarcinoma (intrahepatic bile duct carcinoma)
  • Mixed hepatocellular cholangiocarcinoma
  • Undifferentiated
  • Hepatoblastoma

Envita Medical Centers
Medical Team

Physicians with MD, MD(h), and NMD medical licenses, including certified oncologists, and certified interventional radiologists, striving to provide the latest cancer innovations
22
Pharmacists specializing in integrative agents
7
Nurses trained in precision treatment delivery
40+

Envita’s Unique New Treatments Overcome Challenges for Optimal Results

Our multi-disciplinary team of healthcare professionals work collaboratively to develop a personalized treatment plan which overcomes standard treatment challenges such as chemotherapeutic drug resistance.

According to medical studies, with extended administration of the first-line therapy for advanced stages of HCC, cancer cells can become resistant to the drug, making it ineffective.

To tackle these challenges, our unique new treatments utilize a personalized combination therapy, which includes a targeted blend of natural compounds, chemotherapeutics, immunotherapies, and precision methods of drug deployment. With over two decades of clinical experience, Envita Medical Centers has been able to overcome many of the challenges associated with hepatic cancer treatment planning. Our advanced integrative treatment options and procedures go beyond the standard protocols, enabling our patients to find personalized precision treatment options where other renowned cancer treatment centers in the country are lacking.

Envita’s Precision Oncology Provides Important Quality of Life Metrics

88%* of patients reported symptom score improvement under Envita Medical Centers’ Care
95%* fewer side-effects are experienced by patients receiving precision oncology at Envita Medical Centers

With increased symptom score improvement and fewer side effects, Envita’s four-pillared treatment approach is aimed at providing lasting results. We build a detailed medical blueprint for each individual patient based on these four core steps. Our personalized precision oncology treatment approach is designed to improve patients’ quality of life, increase longevity, and reduce toxicity.

Graph depicting Envita Medical Centers' method

Step 1

Genomic Identification Strikes at the Root Cause

Addressing all the causative factors of each patient’s liver cancer is crucial to provide the best possible chance of a holistic recovery. In our clinical opinion, if the cause of the cancer is not properly addressed, patients end up receiving only palliative treatment meant to optimize quality of life and mitigate suffering.

To get to the root cause of each patient’s liver cancer, we perform an extensive genomic analysis, which is not accessible to all liver cancer patients following standard treatment protocols.

At Envita, we perform in-depth genetic tests for all liver cancer patients, irrespective of their cancer stage or type!

Envita Medical Centers building

The handful of patients who do get access to genomic analysis as part of standard precision oncology, receive a watered-down version of Envita’s detailed liver cancer program. Our proprietary genomic analysis investigates many more parameters than standard oncology genomic testing, allowing us to build a comprehensive plan for attacking liver cancer, while enhancing the patient’s immune system.

Envita Precision Algorithm vs.
Standard Oncology Precision Testing

RNA Transcriptome Genes
Envita Medical Centers: 20,000+
Standard Oncology: Unchecked
SNV/CNV Genes
Envita Medical Centers: 452
Standard Oncology: 309
Rearrangements/Fusion Genes
Envita Medical Centers: 51
Standard Oncology: 27
Microsatellite Instability (MSI)
Envita Medical Centers: Checked
Standard Oncology: Checked
Tumor Mutation Burden (TMB)
Envita Medical Centers: Checked
Standard Oncology: Checked
BRCA 1/2
Envita Medical Centers: Checked
Standard Oncology: Checked
Immunohistochemistry
Envita Medical Centers: Checked
Standard Oncology: Unchecked
Chemosensitivity
Envita Medical Centers: Checked
Standard Oncology: Unchecked
Concurrent Liquid Biopsy
Envita Medical Centers: Checked
Standard Oncology: Unchecked
Exosomal miRNA Analysis
Envita Medical Centers: Checked
Standard Oncology: Unchecked
Circulating Tumor Cells Enumeration
Envita Medical Centers: Checked
Standard Oncology: Unchecked
Pharmacogenomics
Envita Medical Centers: Checked
Standard Oncology: Unchecked
Individualized Therapy Recommendation
Envita Medical Centers: Checked
Standard Oncology: Unchecked
Carcinogenic Exposure - Root Causes
Envita Medical Centers: Checked
Standard Oncology: Unchecked
Inflammation Markers
Envita Medical Centers: Checked
Standard Oncology: Unchecked
Metabolic Target Drivers
Envita Medical Centers: Checked
Standard Oncology: Unchecked

*Individual results may vary. Envita makes no guarantees for outcomes.

If the cause of the cancer is not properly addressed, then the likelihood of recurrence is much higher. Hepatitis, for instance, is a major risk factor for developing HCC. Medical studies show approximately 80% of cases of HCC are associated with cirrhosis related to chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection.

Cirrhosis refers to severe scarring of liver tissues caused by long-term exposure to toxins, like alcohol, or certain infections. At Envita, we are extremely experienced in identifying and treating cancer and its infectious causes, which is why we have published extensively on this topic.

Our dedication to research shows how uniquely qualified and experienced we are at treating not only late-stage progressive cancer, but also, chronic infections which may trigger cancers.

Envita’s personalized treatments address the pathways of cancer progression by incorporating aspects such as inflammatory markers, oncogene downregulation, tumor suppressor gene upregulation, and advanced immunotherapy, to treat the disease core. In our clinical opinion, it is not enough to treat liver cancer alone because treating chronic infections and associated liver diseases is pivotal for providing a comprehensive cancer treatment.

Step 2

Immuno Targeting Checks Further Metastases

The immune system is the first line of defense against cancer and is one of the greatest weapons for cancer treatment, which is why we provide advanced immunotherapy for all our patients, irrespective of cancer stage or type.

Our personalized immunotherapies go beyond basic checkpoint inhibitors or smart drugs to treat patients with late-stage and complex cancers. Our pioneering research and experience in immunotherapy have led us to publish a study on “Immunotherapy in Cancer Treatment”, which explains its potential to treat cancer with significantly less toxicity than chemotherapy and radiation treatments.

Envita’s Ultra Analytes Liquid Biopsy helps in establishing immunotherapy targets, which facilitates proactive treatment of the disease, reducing chances of metastases. Our proprietary liquid biopsy utilizes blood tests to analyze Circulating Tumor Cells (CTCs), which break away from a growing tumor and enter a patient’s bloodstream, spreading the disease to various parts of the body.

Detailed analysis of CTCs establishes the chemo and immunotherapy targets of each individual liver cancer patient, guiding us to the appropriate anti-cancer medications with the highest chance of tumor response.

Envita Medical Centers building

A recent medical study on Current Perspectives in Immunotherapy for Liver Cancer show how treatments in development involving cancer vaccines and natural killer cell-mediated therapy may be beneficial for patients. However, we at Envita are already offering these advanced treatments to help our patients outperform this disease.

Step 3

Personalized Drug Design May Debulk Liver Tumors

In our clinical opinion, a personalized combination of FDA (Food and Drug Administration) approved drugs, repurposed drugs, and custom-compounded adjuvants are critical for effectively striking at each patient’s unique liver cancer. This personalized drug design may help in debulking liver tumors, thus helping in tackling certain unresectable cancers.

FDA Approved Drugs
Optimized for your cancer mutations.
Repurposed Drugs
Off-label use of approved medications
Custom Compounded Adjuvants
Genetically typed for each patient.

At Envita, treatment is not limited to the existing drugs available on the market, as we custom-design adjuvants at our in-house pharmacy to impact the unique set of biomarkers, causing the disease and its progression in each individual patient. These adjuvants are based on advanced phytotherapeutics, including plant extracts and herbs, which have proven impactful against specific cancer biomarkers, without causing severe side effects.

Step 4

Precision Deployment for Better Results

Our proprietary new treatments utilize precision deployment mechanisms to deliver targeted therapies to the affected area, without damaging the healthy cells in the adjoining regions. We deploy these powerful combinations of personalized medications either intravenously or through minimally invasive interventional radiology procedures.

At Envita, you gain access to our proprietary treatments as well as the latest offerings in standard liver cancer treatment, but we enhance their efficacy by including advanced immunotherapy in the care plan of each individual patient. For example, we do all types of ablations, such as radiofrequency ablations, cryoablations, and microwave ablations, but we follow-up with targeted immunotherapies for each individual liver cancer patient to enhance the efficacy of these procedures.

The following are some of our proprietary treatments:

CIPI™ (Chemo Immuno Precision Injections)

CIPI™, or Chemo Immuno Precision Injections, is a proprietary form of tumor embolization that Envita utilizes to treat inoperable or fibrous tumors. It is extremely useful for treating liver cancer and liver metastases because it can circumvent factors that traditionally make this cancer challenging to treat.

Not only is liver cancer often inoperable, but it may even resist penetration by normal chemotherapy methods due to the thick stroma around the tumor. However, our proprietary procedure is specially designed to overcome all these hurdles.

Unlike other tumor embolization methods, like hepatic artery embolization or Trans arterial Chemoembolization (TACE), CIPI™ takes a step further to deploy personalized chemotherapy and immunotherapy agents directly at the site of the tumor. Targeted chemotherapy and adjunctive immune modulating agents are injected into the tumor through a thin catheter for precision absorption of medications directly into the tumor. These personalized medications make CIPI™ go beyond other forms of tumor embolization, as it creates a systemic immune response that works to attack metastasized cancer cells elsewhere in the body.

Envita's CIPI™ vs.
Standard Surgery

Minimally invasive so it can be performed within 40-50 minutes, without the need for large surgical incisions.
Envita's CIPI™: Checked
Standard Surgery: Unchecked
Can be performed multiple times, even at close intervals, because there is minimal risk of post-op complications.
Envita's CIPI™: Checked
Standard Surgery: Unchecked
No need for general anesthesia, reducing the health risks that can result from being put into a medically induced coma to perform an invasive surgery.
Envita's CIPI™: Checked
Standard Surgery: Unchecked
Faster recovery time as compared to traditional surgery, due to the minimally invasive administration.
Envita's CIPI™: Checked
Standard Surgery: Unchecked
Provides direct tumor targeting, which delivers patient-specific genomic agents into the tumor.
Envita's CIPI™: Checked
Standard Surgery: Unchecked
Causes a systemic immune response where the immune system is reactivated to find and attack other metastatic cancer sites in the body.
Envita's CIPI™: Checked
Standard Surgery: Unchecked
Performed by highly trained medical professionals in an outpatient setting, so there is no need of hospital stays for recovery.
Envita's CIPI™: Checked
Standard Surgery: Unchecked

*Individual results may vary. Envita makes no guarantees for outcomes.

GTFC™ (Genetically Targeted Fractionated Chemotherapy)

Envita Medical Centers’ proprietary precision targeted low-dose chemotherapy has the potential to help patients respond better than standard untargeted chemotherapy, as GTFC™ includes micro-dosed medications with the highest potential of impacting each patient’s unique cancer biomarkers.

Our peer-reviewed and published study discusses the importance of the use of biomarkers to enhance decision making with regard to the molecular profile of a person’s cancer.

The targeted medications enable GTFC™ to perform at a precision level over standard maximum dose chemotherapy, which is generally used in advanced stages of liver cancer when patients do not respond to other treatments. However, GTFC™’s low dose targeted medications have a higher potential of impacting the cancer while causing fewer side-effects, as compared to standard untargeted chemotherapy.

Envita's GTFC™ vs.
Standard Chemotherapy

Helps to improve chemotherapy delivery to the tumor using a "Trojan Horse" delivery mechanism.
Envita's GTFC™: Checked
Standard Chemotherapy: Unchecked
Uses genetic molecular profiling to understand all the facets of each patient's specific cancer.
Envita's GTFC™: Checked
Standard Chemotherapy: Unchecked
Uses targeted treatment to enhance the mechanism of cancer kill.
Envita's GTFC™: Checked
Standard Chemotherapy: Unchecked
Uses microdosed (fractionated) chemotherapies, reducing the chances of impacting healthy cells.
Envita's GTFC™: Checked
Standard Chemotherapy: Unchecked
Minimizes toxicity to normal cells, lowering the chance of side-effects related to administration.
Envita's GTFC™: Checked
Standard Chemotherapy: Unchecked
Uses patient-specific supportive immunotherapy to strengthen the immune system.
Envita's GTFC™: Checked
Standard Chemotherapy: Unchecked
Aims to reduce multidrug resistance by administering 10 - 20% of the medication delivered in maximum dose chemo.
Envita's GTFC™: Checked
Standard Chemotherapy: Unchecked
Allows custom-compounded medications to be readministered in tandem to suit each patient's individual cancer mutations.
Envita's GTFC™: Checked
Standard Chemotherapy: Unchecked

*Individual results may vary. Envita makes no guarantees for outcomes.

Watch Out for These Liver Cancer Symptoms

  • Jaundice, marked by yellowing of the skin and eyes
  • Weight loss
  • Loss of appetite
  • Fatigue
  • Pain in the abdomen
  • Nausea or vomiting
  • Cirrhosis, a late-stage liver disease, determined via blood-tests, imaging tests, like CT scan and MRI, or liver biopsy

Call Us Now

While some patients may find success with conventional treatment methods, the vast majority of patients we treat at Envita have already exhausted the traditional methods and are seeking more advanced care. Our clinical experience with liver cancer and other inoperable tumors has led to the development of specialized treatment options which may be beneficial for patients. Our multi-disciplinary team goes through 1,500 hours of training to adapt to this integrative personalized precision oncology approach.

If you or a loved one has any questions regarding liver cancer, do not hesitate to call us at 866-830-4576. We are looking forward to hearing from you. May God bless you on your journey to healing!

* The 3rd party actuarial response data is based on an analysis of records for 87 out of 129 patients that participated in Envita’s Treatment Program in 2020. 42 patients were removed from the cohort due to the patients’ inability to start or complete Envita’s prescribed treatment for a variety of reasons, including but not limited to, advanced disease state, disease progression, or inability to travel.

Choose Envita Medical Centers

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